Introduction

Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms arising from the diffuse neuroendocrine cell system and most commonly originate from the gastrointestinal tract, pancreas, and bronchopulmonary system [1]. Primary NETs arising exclusively within the mesentery, without any identifiable gastrointestinal or pancreatic primary lesion, represent an exceptionally rare clinical entity, with only a limited number of cases documented in the literature [2,3].

Their non-specific clinical presentation - typically an asymptomatic or mildly symptomatic abdominal mass - and rarity frequently lead to diagnostic delay and misdiagnosis as other mesenteric tumors such as gastrointestinal stromal tumors (GISTs), desmoid tumors, or lymphomas [2]. We present a case of a primary mesenteric NET in an elderly female, highlighting the diagnostic workup, surgical management, and pertinent histopathological and immunohistochemical findings. This case report adheres to the CARE guidelines for case report reporting.