Abbreviations

ABR: Auditory brainstem response AKI: Acute kidney injury AMPK: AMP-activated protein kinase BAX: BCL2-associated X protein BCL-2: B-cell lymphoma 2 BECN1: Beclin 1 BFA: Brefeldin A BIRC5: Baculoviral IAP repeat containing 5 CCK-8: Cell Counting Kit-8 CCL2: C-C motif chemokine ligand 2 cKO: Conditional knockout co-IP: Co-immunoprecipitation CQ: Chloroquine CSF1: Colony stimulating factor 1 CtBP2: C-terminal binding protein 2 CXCL: C-X-C motif chemokine ligand CXCL1: C-X-C motif chemokine ligand 1 CXCL3: C-X-C motif chemokine ligand 3 CXCL10: C-X-C motif chemokine ligand 10 EDTA: Ethylenediaminetetraacetic acid disodium salt FAM: Fluorescein amidite FDA: U.S. Food and Drug Administration GADD45A: Growth arrest and DNA damage-inducible alpha GluR2: AMPA-type glutamate receptor subunit 2 GO: Gene Ontology GSEA: Gene set enrichment analysis HO-1: Heme oxygenase-1 IBA1: Ionized calcium-binding adaptor molecule 1 IHC: Inner hair cell IL-17: Interleukin-17 IPR: InterPro IκB: Inhibitor of nuclear factor κB JNK: c-Jun N-terminal kinase KEGG: Kyoto Encyclopedia of Genes and Genomes KOGs: Eukaryotic orthologous groups of proteins LBP: Lipopolysaccharide-binding protein LC3-II: Microtubule-associated protein 1 light chain 3-II LC3B-II: Microtubule-associated protein 1 light chain 3 beta-II LPS: Lipopolysaccharide MKK4: Mitogen-activated protein kinase kinase 4 NF-κB: Nuclear factor κB NF-κB1: Nuclear factor κB subunit 1 Nrf2: Nuclear factor erythroid 2-related factor 2 OHC: Outer hair cell PBS: Phosphate-buffered saline PCR: Polymerase chain reaction PFA: Paraformaldehyde PI: Propidium iodide PIK3C3: Phosphatidylinositol 3-kinase catalytic subunit type 3 PSC: Posterior semicircular canal RELA: RELA proto-oncogene, NF-κB subunit ROS: Reactive oxygen species SGN: Spiral ganglion neuron

SV:Strial Vascularis SOX2: SRY-box transcription factor 2 SPL: Sound pressure level SQSTM1: Sequestosome 1 TDT: Tucker-Davis Technologies TNF: Tumor necrosis factor TNF-α: Tumor necrosis factor alpha TOM20: Translocase of outer mitochondrial membrane 20 homolog TOP2A: DNA topoisomerase II alpha γ-H2A.X: Phosphorylated H2A histone family member X