Limitations

This study has limitations. The AVN relies on voluntary reporting of FIA, which does not allow prevalence estimation. Dietary habits were not collected; findings are not specific to individuals following a PBD. In addition, CRD were not systematically available for all cases, partly due to the long study period beginning in 2002, prior to the widespread use of CRD in routine clinical practice in France. Analyses were bivariate; as cofactors, comorbidities, prior diagnosis, and age are likely interrelated, thus findings represent associations rather than independent effects. Finally, some variables contained missing data, and analyses were therefore based on available observations.