Work overview

Section 05 of 11

Conclusion

Transcriptomic and genetic evidence highlights EHHADH in a FUNDC1-associated mitochondrial network in diabetic nephropathy

Yuzhi Chen, Demei Ying, Xuli Guo, Shaozhe Wang, Wenjing Liu, Siwen Wang, Na Kuang, Jiahan Li, and Nan Chen · 2026

Contents

Section 05 of 11

  1. 01Background
  2. 02Methods
  3. 03Results
  4. 04Discussion
  5. 05Conclusion
  6. 06CRediT authorship contribution statement
  7. 07Availability of data and materials
  8. 08Ethics approval and consent to participate
  9. 09Consent for publication
  10. 10Funding
  11. 11Declaration of competing interests
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Work overview

Section 5 of 11

Conclusion

Yuzhi Chen, Demei Ying, Xuli Guo, Shaozhe Wang, Wenjing Liu, Siwen Wang, Na Kuang, Jiahan Li, and Nan Chen · about 1 minutes

Original source ↗

In this study, integrating transcriptomic analysis and SMR-based genetic association analysis, we identified a FUNDC1-associated mitochondrial regulatory network and prioritized EHHADH as a genetically supported candidate gene in DN-associated renal injury. Genetically predicted lower EHHADH expression was associated with increased DN risk, and both FUNDC1 and EHHADH were enriched in mitochondrial metabolic pathways, suggesting a potential association between mitochondrial quality control and fatty acid metabolism. Dysregulation of the FUNDC1–EHHADH-associated mitochondrial regulatory network may contribute to oxidative stress-related processes in DN, providing potential insights into mitochondrial homeostasis as a therapeutic consideration.