Work overview

Section 04 of 04

Conclusions

Severe Warm Autoimmune Hemolytic Anemia With Profound Anemia Requiring Multimodal Immunosuppressive Therapy

Helena Awada, Rohan Chawla, Yanicka Shepherd, Cameron Bondy, and David Yetenikyan · 2026

Contents

Section 04 of 04

  1. 01Introduction
  2. 02Case presentation
  3. 03Discussion
  4. 04Conclusions
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Work overview

Section 4 of 4

Conclusions

Helena Awada, Rohan Chawla, Yanicka Shepherd, Cameron Bondy, and David Yetenikyan · about 1 minutes

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wAIHA is an uncommon but potentially life-threatening condition requiring prompt recognition and timely immunosuppressive therapy. This case demonstrates successful management of fulminant secondary wAIHA associated with evolving systemic autoimmunity using corticosteroids, IVIG, and carefully guided transfusion support without the need for rituximab or splenectomy. Although the patient's DAT demonstrated both IgG and C3 positivity, additional testing to definitively exclude mixed AIHA was unavailable and represents a limitation of this report. Early multidisciplinary management, prompt treatment of severe symptomatic anemia, and continued rheumatologic follow-up remain essential to optimize outcomes in patients presenting with autoimmune hemolytic anemia.