Work overview

Section 05 of 10

Conclusions

psiTPTE22-HERV functions as a tumor suppressor by inhibiting PI3K/AKT/mTOR/EIF4E signaling

Fei Xu, Mengwen Zhang, Suzhan Zhang, Yao Zeng, Shu Zheng, and Jessie Qiaoyi Liang · 2025

Contents

Section 05 of 10

  1. 01Introduction
  2. 02Material and methods
  3. 03Results
  4. 04Discussion
  5. 05Conclusions
  6. 06CRediT authorship contribution statement
  7. 07Ethics declaration
  8. 08Data availability
  9. 09Funding
  10. 10Conflict of interests
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Work overview

Section 5 of 10

Conclusions

Fei Xu, Mengwen Zhang, Suzhan Zhang, Yao Zeng, Shu Zheng, and Jessie Qiaoyi Liang · about 1 minutes

Original source ↗

In this study, we identified psiTPTE22-HERV as a novel tumor suppressor that was down-regulated by promoter methylation in gastric cancer. psiTPTE22-HERV exerts tumor-suppressive functions by down-regulating EIF4E via inhibition of the PI3K/AKT/mTOR pathway. Furthermore, down-regulation of psiTPTE22-HERV in primary tumors serves as an independent risk factor for poor prognosis in patients with gastric cancer.