Work overview

Section 01 of 05

Introduction

Probable paradoxical pyoderma gangrenosum associated with secukinumab in a patient with severe plaque psoriasis

Carla Fernanda Genevcius, Raphael Fernando Fonseca Genevcius, Luiz Carlos da Silva, Pedro Marabini Filho, and Livia Moura Tessarini Gandolfi · 2026

Contents

Section 01 of 05

  1. 01Introduction
  2. 02Case report
  3. 03Discussion
  4. 04Conclusion
  5. 05Conflicts of interest
Text size
Work overview

Section 1 of 5

Introduction

Carla Fernanda Genevcius, Raphael Fernando Fonseca Genevcius, Luiz Carlos da Silva, Pedro Marabini Filho, and Livia Moura Tessarini Gandolfi · about 1 minutes

Original source ↗

Pyoderma gangrenosum (PG) is an uncommon neutrophilic dermatosis characterized by rapidly progressive painful ulcerations and difficult diagnosis.1,2 Histopathologic findings are frequently nonspecific, making clinicopathologic correlation essential.3,4

Drug-associated PG has become increasingly recognized with the expanding use of biologic therapies.5 Secukinumab, an interleukin-17A inhibitor widely used for psoriasis, has rarely been associated with paradoxical PG.6, 7, 8, 9, 10 We report a probable case of paradoxical PG associated with secukinumab in a patient with severe plaque psoriasis and exuberant scalp involvement.