Work overview

Section 05 of 07

Conclusion and Future Directions

Network pharmacology, molecular docking and In vivo validation reveal the neuroprotective effects of TT-TeMac™ against cholinergic dysfunction and hippocampal lesions

Bruno Dupon Akamba Ambamba, Messanga me Ngo'o Jonathan, Akono Fama Yves Marc, Nyabissick Mondjiep Sandrine, Njayou Mbouangouore Ingrid Reine, Ngarchindi Emmanuel, Nkodo Abega Laurent, Njanjo Ejanmoua Merveille La Blonde, Ebogo Enyegue Françoise Alexandra, Fils Armand Ella, Damaris Enyegue Mandob, and Judith Laure Ngondi · 2026

Contents

Section 05 of 07

  1. 01Introduction
  2. 02Materials and Methods
  3. 03Results
  4. 04Discussion
  5. 05Conclusion and Future Directions
  6. 06CRediT authorship contribution statement
  7. 07Declaration of Competing Interest
Text size
Work overview

Section 5 of 7

Conclusion and Future Directions

Bruno Dupon Akamba Ambamba, Messanga me Ngo'o Jonathan, Akono Fama Yves Marc, Nyabissick Mondjiep Sandrine, Njayou Mbouangouore Ingrid Reine, Ngarchindi Emmanuel, Nkodo Abega Laurent, Njanjo Ejanmoua Merveille La Blonde, Ebogo Enyegue Françoise Alexandra, Fils Armand Ella, Damaris Enyegue Mandob, and Judith Laure Ngondi · about 1 minutes

Original source ↗

This study demonstrates that TT-TeMac™, through its bioactive compounds (terminolic acid, sericic acid, arjunolic acid, gallic acid, ellagic acid and its derivatives), targets 15 genes common to cholinergic dysfunction. Network pharmacology and molecular docking confirmed the strong interaction between the compounds and key genes of the cholinergic pathway. Moreover, in vivo validation revealed that TT-TeMac™ effectively counteracts scopolamine-induced memory impairment by inhibiting cholinesterase activity and preserving hippocampal neuronal integrity. These results suggest that TT-TeMac™ has promising therapeutic potential for the management of cognitive decline in AD. Given the multifactorial nature of AD, the multitarget action of TT-TeMac™ highlights its advantage over single-target therapies, potentially offering a more comprehensive approach to mitigating neurodegeneration. Future studies should validate its effects on cellular models of cholinergic dysfunction, thus better highlighting the mechanisms of action.