Work overview

Section 01 of 05

Introduction

Impact of Pre-injury Statin Use on Mortality and Short-Term Clinical Outcomes Following Intracerebral Hemorrhage: A Propensity-Matched Cohort Study

Katelyn A Robertson, Kaitlyn Blake, Ashley Thompson, Rejoice Spivey, Tyler Thompson, Mrinalini Deverapalli, and Miriam Michael · 2026

Contents

Section 01 of 05

  1. 01Introduction
  2. 02Materials and methods
  3. 03Results
  4. 04Discussion
  5. 05Conclusions
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Work overview

Section 1 of 5

Introduction

Katelyn A Robertson, Kaitlyn Blake, Ashley Thompson, Rejoice Spivey, Tyler Thompson, Mrinalini Deverapalli, and Miriam Michael · about 1 minutes

Original source ↗

Intracerebral hemorrhage (ICH) accounts for approximately 10-15% of all strokes but contributes disproportionately to stroke-related mortality and disability [1]. Despite advances in neurocritical care, outcomes remain poor, and effective therapeutic interventions are limited.

Statins are widely prescribed for the prevention of cardiovascular and cerebrovascular disease. Beyond their lipid-lowering effects, statins exhibit pleiotropic properties, including anti-inflammatory, antioxidative, and endothelial-stabilizing effects, which may influence neurological outcomes [2,3]. However, their role following ICH remains controversial. While some studies have reported an association between statin use and improved survival or functional outcomes, concerns persist regarding a potential increased risk of hemorrhage and hematoma expansion [4,5].

Given these conflicting findings, further investigation using large, real-world datasets is warranted. Using a large multicenter electronic health record database, this retrospective observational study evaluated the association between pre-injury statin use and short-term clinical outcomes following ICH.