Conflict of Interest

Scott J. Keating and Ann M. Menzie are employees of Vertex Pharmaceuticals Incorporated, and may own stock or stock options in the company. Kelly L. Johnston is employed by IQVIA, a consulting firm retained by Vertex Pharmaceuticals Incorporated to conduct research pertaining to this work; KD Jacobs and Lauren A. Crowder are former employees of IQVIA. Scott G. Weiner is an employee of Brigham and Women’s Hospital, which received grants or contracts from the National Institutes of Health, Foundation for Opioid Response Efforts, and Yale University Elevance Foundation; received consulting fees from Vertex Pharmaceuticals Incorporated and Cessation Therapeutics.