Work overview

Section 10 of 14

CONCLUSION

Effects of proton therapy on the tumor immune system and clinical implications: A review

Rundong Liu, Mei Tao, Min Fu, Yingjia Hu, Zhen Tao, and Guangyuan Hu · 2026

Contents

Section 10 of 14

  1. 01INTRODUCTION
  2. 02BASIC PRINCIPLES OF PROTON THERAPY
  3. 03IMPACT OF PROTON THERAPY ON DRAINING LYMPH NODES
  4. 04IMPACT OF PROTON THERAPY ON PERIPHERAL BLOOD IMMUNE CELLS
  5. 05IMPACT OF PROTON THERAPY ON TUMOR CELL IMMUNE RESPONSE
  6. 06IMPACT OF PROTON THERAPY ON THE TIME
  7. 07EFFECTS OF PROTON THERAPY COMBINED WITH IMMUNOTHERAPY
  8. 08EFFECTS OF PROTON THERAPY COMBINED WITH CHEMOTHERAPY
  9. 09CURRENT CHALLENGES AND FUTURE DIRECTIONS
  10. 10CONCLUSION
  11. 11AUTHOR CONTRIBUTIONS
  12. 12INSTITUTIONAL REVIEW BOARD STATEMENT
  13. 13INFORMED CONSENT STATEMENT
  14. 14CONFLICTS OF INTEREST STATEMENT
Text size
Work overview

Section 10 of 14

CONCLUSION

Rundong Liu, Mei Tao, Min Fu, Yingjia Hu, Zhen Tao, and Guangyuan Hu · about 1 minutes

Original source ↗

In the evolving field of cancer treatment, proton therapy is a promising modality owing to its high efficacy and low toxicity. This review highlights that proton therapy selectively targets cancer cells, spares healthy tissue, and induces a unique immune response in peripheral blood immune cells, tumor cells, and the TIME. In addition, combining proton therapy with immunotherapy and/or chemotherapy may benefit patients with various types of cancer. We hope that this review will provide a better understanding of the impact of proton therapy on the immune system and shed light on potential combination treatment strategies.