Work overview

Section 01 of 09

Introduction

Clinical Decision‐Making in Peptic Esophageal Stenosis: To PEG or Not to PEG?

Junus Benjamin Cokovic, Christian Prinz, and Leonard Fehring · 2026

Contents

Section 01 of 09

  1. 01Introduction
  2. 02Case History
  3. 03Investigations and Treatments
  4. 04Outcome and Results
  5. 05Discussion
  6. 06Author Contributions
  7. 07Funding
  8. 08Consent
  9. 09Conflicts of Interest
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Work overview

Section 1 of 9

Introduction

Junus Benjamin Cokovic, Christian Prinz, and Leonard Fehring · about 1 minutes

Esophageal strictures, defined as pathological luminal narrowing of the esophagus, represent a relatively uncommon condition with increasing incidence in older populations [1]. Clinically, they manifest predominantly as progressive dysphagia to solid and/or liquid intake and are frequently accompanied by non‐cardiac chest pain [2]. In primary care settings, the majority of cases are peptic in origin, arising as a complication of gastroesophageal reflux disease (GERD). GERD is the most prevalent gastrointestinal disorder worldwide, affecting approximately 20% of individuals in Western countries, and is mainly driven by lifestyle factors, such as alcohol consumption, smoking, and weight gain [3]. While short‐term mucosal irritation is often self‐limiting, persistent or severe injury to the esophageal epithelium leads to significant scarring, ultimately resulting in stenosis [4]. Furthermore, sustained epithelial damage and cellular stress increase the risk of malignant transformation [5].

In patients with esophageal stenosis, adequate oral nutritional intake is frequently compromised due to mechanical obstruction and progressive dysphagia. In such cases, placing a percutaneous endoscopic gastrostomy (PEG) tube often represents the most effective method to bypass the stenotic segment and ensure sufficient enteral nutrition. During this procedure, a large‐bore plastic catheter is inserted transdermally into the stomach under endoscopic guidance, allowing for direct access to the gastrointestinal lumen [6]. The PEG tube is specifically intended for long‐term enteral nutrition. Current clinical guidelines recommend that PEG tube placement be considered when enteral feeding is expected to be necessary for at least 2–3 weeks [7]. Prospective clinical studies have shown that in most cases, supplemental nutrition via PEG tube can prevent progressive weight loss and thus maintain nutritional status, although complete recovery is rare even in benign conditions [8].