Work overview

Section 05 of 05

Conclusions

AKI as a systemic syndrome and its impact on other organ systems

Benedetta Manca, Lui Forni, Hendrik Booke, Sven Meuth, Jay Koyner, Ashley La, and Alexander Zarbock · 2026

Contents

Section 05 of 05

  1. 01Background
  2. 02Consequences of AKI
  3. 03AKI and its impact on organ systems
  4. 04AKI trial endpoints: surrogate markers of AKI-associated complications
  5. 05Conclusions
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Work overview

Section 5 of 5

Conclusions

Benedetta Manca, Lui Forni, Hendrik Booke, Sven Meuth, Jay Koyner, Ashley La, and Alexander Zarbock · about 1 minutes

Original source ↗

Although the molecular mechanisms are not fully elucidated, the literature consistently reports the association between the failing kidneys and other organ dysfunctions and that AKI-associated complications are associated with an increased morbidity and mortality. Unfortunately, no therapies directly targeting AKI exist; therefore, physicians can only apply preventive and supportive measures. As these AKI-associated complications directly influence the outcome of the patients, they may be considered as endpoints in AKI trials.