Work overview

Section 05 of 05

5. Conclusion

A single-stranded DNA virus replicates in the mitochondria of a marine oomycete

Kohei Sakuta, Mart Krupovic, Ondřej Hejna, Cristiana Maia, Marília Horta Jung, Ken Komatsu, Hiromitsu Moriyama, Thomas Jung, and Leticia Botella · 2026

Contents

Section 05 of 05

  1. 011. Introduction
  2. 022. Materials and methods
  3. 033. Results
  4. 044. Discussion
  5. 055. Conclusion
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Work overview

Section 5 of 5

5. Conclusion

Kohei Sakuta, Mart Krupovic, Ondřej Hejna, Cristiana Maia, Marília Horta Jung, Ken Komatsu, Hiromitsu Moriyama, Thomas Jung, and Leticia Botella · about 1 minutes

Original source ↗

HthCRESSV1 represents a circular DNA virus with unique genomic features and a close association with oomycete mitochondria. Its genome encodes a divergent Rep protein and a membrane-associated HP conserved in mitogenomes, suggesting prolonged interaction with the mitochondrial compartment. The absence of recognizable capsid genes and the presence of repetitive regulatory elements point to a separated evolutionary trajectory within cressdnaviricots. Together, these findings expand current views of CRESS virus diversity and highlight mitochondria as a potential niche for circular DNA replicons in eukaryotes.