Work overview

Section 07 of 07

Supporting information

A Comprehensive Comparative Analysis of Sequence‐Based Deep Learning Models for Single‐Cell Genomics

Guoxia Wen, Jiaqi Li, Hanyu Wu, Jialing Fang, Yuting Fu, Mengmeng Jiang, Yuqing Mei, Rui Xu, Yuxuan Du, Siran Chu, Guoji Guo, Xiaoping Han, and Jingjing Wang · 2026

Contents

Section 07 of 07

  1. 01Full text
  2. 02Author Contributions
  3. 03Funding
  4. 04Ethics Statement
  5. 05Consent
  6. 06Conflicts of Interest
  7. 07Supporting information
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Work overview

Section 7 of 7

Supporting information

Guoxia Wen, Jiaqi Li, Hanyu Wu, Jialing Fang, Yuting Fu, Mengmeng Jiang, Yuqing Mei, Rui Xu, Yuxuan Du, Siran Chu, Guoji Guo, Xiaoping Han, and Jingjing Wang · about 1 minutes

Figure S1: Predictive performance of the CNN model on the different scRNA‐seq technologies.

Figure S2: Scatter plot of actual and predicted gene expression values from the logistic regression analysis trained on the mESCs dataset, Human PBMCs datasets and Pancreas dataset.

Figure S3: Benchmark of hyper‐parameters on predictive performance of the CNN model.

Figure S4: The exploration of advanced model architectures.

Figure S5: The exploration of Transformer architectures in the 10X genomics platform.

Figure S6: Function enrichment on genes from MCA embryonic dataset that predicted to expressed but not detected by scRNA‐seq.

Figure S7: Evaluation of the CNN model with MTL framework on rare cell types.

Table S1: Characteristics of different single‐cell sequencing methods used in the study.

Table S2: Performance details of scRNA‐seq methods for the CNN model.

Table S3: Statistical comparison of baseline and MAGIC‐imputed data across scRNA‐seq platforms.

Table S4: Summary statistics of normalized expression values across three datasets.